Anaphylaxis From Tolmetin
1978; American Medical Association; Volume: 240; Issue: 3 Linguagem: Inglês
10.1001/jama.1978.03290030064025
ISSN1538-3598
Autores Tópico(s)Urticaria and Related Conditions
ResumoTOLMETIN SODIUM (Tolectin) is one of the newer nonsteroidal anti-inflammatory agents used in the management of rheumatoid arthritis. The package insert accompanying tolmetin includes many adverse effects of the drug, but there is no mention of anaphylactic shock induced by this agent. This report describes two patients in whom anaphylactic shock developed within 15 minutes of ingesting two 200-mg tolmetin sodium tablets. Report of Cases Case 1.— A 43-year-old woman was admitted to University of California at Los Angeles Hospital for anaphylactic shock. She had a three-year history of rheumatoid arthritis functional class 2, and met the American Rheumatism Association classification for definite rheumatoid arthritis. Previously, she had been treated with phenylbutazone. Gold sodium thiomalate therapy had been discontinued one year before admission because of severe generalized toxic dermatitis after a total of 260 mg had been given. Six months before admission, a facial rash had developed while taking 500
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