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Investigation of Anti-Inflammatory and Antinociceptive Activities of trans -Dehydrocrotonin, a 19-Nor-Clerodane Diterpene from Croton cajucara . Part 1

1996; Thieme Medical Publishers (Germany); Volume: 62; Issue: 05 Linguagem: Inglês

10.1055/s-2006-957925

1439-0221

J.C.T. Carvalho, Maria João Silva, Maria Aparecida Medeiros Maciel, Ângelo da Cunha Pinto, Domingos Sávio Nunes, Ronaldo Lima, Jairo K. Bastos, S J Sarti,

Traditional and Medicinal Uses of Annonaceae

The anti-inflammatory and antinociceptive effects of trans-dehydrocrotonin, isolated from the bark of Croton cajucara (Euphorbiaceae), were investigated using several animal models. The trans-dehydrocrotonin produced a significant inhibition of carrageenin-induced paw edema and cotton pellet granuloma in rats. It also inhibited the writhings in mice induced by acetic acid, but did not show a significant effect in the hot-plate test in mice. The LD50 of t-DCTN was 555.0 mg/kg (p.o.) for mice.