Effect of Somatostatin (Growth Hormone Inhibiting Factor: GIF) on TRH-induced TSH Release in Rats
1974; Japan Endocrine Society; Volume: 21; Issue: 5 Linguagem: Inglês
10.1507/endocrj1954.21.449
ISSN2185-6370
AutoresMasafumi Utsumi, Hiroyuki Makimura, Akihisa Yamada, M Tateiwa, Hidetaro Mori, T Kusaka, M Sakoda, Shigeaki Baba,
Tópico(s)Pituitary Gland Disorders and Treatments
ResumoIntravenous preadministration of somatostatin (Growth Hormone Inhibiting Factor: GIF) inhibited TRH-induced TSH release in rats anesthesized by pentobarbitulate. There was dose dependent negative interaction between the inhibitory effect of GIF and releasing effect of TRH. TSH releasing effect of small dose of TRH was inhibited completely by preadministration of GIF, while large dose of TRH overcame the inhibitory effect of GIF. The mechanism responsible for inhibitory effect of GIF on TRH-induced release was discussed.
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