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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

DNA damage in brain cells of mice treated with an oxidized form of apomorphine

2003; Elsevier BV; Volume: 114; Issue: 1 Linguagem: Inglês

10.1016/s0169-328x(03)00127-x

ISSN

1872-6941

Autores

Jaqueline Nascimento Picada, Débora G. Flores, Cláudio Galeano Zettler, Norma Possa Marroni, Rafael Roesler, João Antônio Pêgas Henriques,

Tópico(s)

DNA Repair Mechanisms

Resumo

We investigated whether systemic injection of apomorphine and its oxidation derivative 8-oxo-apomorphine-semiquinone (8-OASQ) could induce DNA damage in mice brain, using the single-cell gel assay. 8-OASQ induced DNA damage in the brains at 1 and 3 h, but not at 24 h after treatment whereas apomorphine induced a slight increase in brain DNA damage frequency at 3 h after treatment, suggesting that both drugs display genotoxic activity in brain tissue.

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