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Combining Designer Cells and Click Chemistry for a One‐Pot Four‐Step Preparation of Enantiopure β‐Hydroxytriazoles

2010; Wiley; Volume: 352; Issue: 13 Linguagem: Inglês

10.1002/adsc.201000502

1615-4169

Wiktor Szymański, Christiaan P. Postema, Chiara Tarabiono, Florian Berthiol, Lachlan S. Campbell‐Verduyn, S. De Wildeman, Johannes G. de Vries, Ben L. Feringa, Dick B. Janssen,

Carbohydrate Chemistry and Synthesis

Abstract The multistep catalytic process using designer cells, either added as freshly prepared suspensions or as stable lyophilized powder, and click reaction can be performed in one pot. The sequence of four reactions allows the production of both enantiomers of β‐hydroxytriazoles with high enantiomeric excess.