Blockade of Ethanol-Induced Behavioral Sensitization by Sodium Butyrate: Descriptive Analysis of Gene Regulations in the Striatum
2013; Wiley; Volume: 37; Issue: 7 Linguagem: Inglês
10.1111/acer.12088
ISSN1530-0277
AutoresRémi Legastelois, Béatrice Botia, Mickaël Naassïla,
Tópico(s)Neuroinflammation and Neurodegeneration Mechanisms
ResumoAlcoholism: Clinical and Experimental ResearchVolume 37, Issue 7 p. 1143-1153 Original Article Blockade of Ethanol-Induced Behavioral Sensitization by Sodium Butyrate: Descriptive Analysis of Gene Regulations in the Striatum Rémi Legastelois, Rémi Legastelois INSERM ERI 24 , Groupe de Recherche sur l'Alcool et les Pharmacodépendances (GRAP), UFR de Pharmacie, Structure Fédérative de Recherche CAP-Santé, Université de Picardie Jules Verne, Amiens, FranceSearch for more papers by this authorBéatrice Botia, Béatrice Botia INSERM ERI 24 , Groupe de Recherche sur l'Alcool et les Pharmacodépendances (GRAP), UFR de Pharmacie, Structure Fédérative de Recherche CAP-Santé, Université de Picardie Jules Verne, Amiens, FranceSearch for more papers by this authorMickaël Naassila, Corresponding Author Mickaël Naassila INSERM ERI 24 , Groupe de Recherche sur l'Alcool et les Pharmacodépendances (GRAP), UFR de Pharmacie, Structure Fédérative de Recherche CAP-Santé, Université de Picardie Jules Verne, Amiens, FranceReprint requests: Mickaël Naassila, INSERM ERI 24, GRAP, Université de Picardie Jules Verne, UFR de Pharmacie, 1 rue des Louvels, Amiens, France; Tél.: +33-322827758; Fax: +33-322827672; E-mail: [email protected]Search for more papers by this author Rémi Legastelois, Rémi Legastelois INSERM ERI 24 , Groupe de Recherche sur l'Alcool et les Pharmacodépendances (GRAP), UFR de Pharmacie, Structure Fédérative de Recherche CAP-Santé, Université de Picardie Jules Verne, Amiens, FranceSearch for more papers by this authorBéatrice Botia, Béatrice Botia INSERM ERI 24 , Groupe de Recherche sur l'Alcool et les Pharmacodépendances (GRAP), UFR de Pharmacie, Structure Fédérative de Recherche CAP-Santé, Université de Picardie Jules Verne, Amiens, FranceSearch for more papers by this authorMickaël Naassila, Corresponding Author Mickaël Naassila INSERM ERI 24 , Groupe de Recherche sur l'Alcool et les Pharmacodépendances (GRAP), UFR de Pharmacie, Structure Fédérative de Recherche CAP-Santé, Université de Picardie Jules Verne, Amiens, FranceReprint requests: Mickaël Naassila, INSERM ERI 24, GRAP, Université de Picardie Jules Verne, UFR de Pharmacie, 1 rue des Louvels, Amiens, France; Tél.: +33-322827758; Fax: +33-322827672; E-mail: [email protected]Search for more papers by this author First published: 12 March 2013 https://doi.org/10.1111/acer.12088Citations: 42 The first two authors contributed equally to the work. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Background Behavioral sensitization induced by repeated ethanol (EtOH) exposure may play a critical role in the development of alcohol dependence. Because recent data demonstrate that histone deacetylase inhibitor (HDACi) may be of interest in the treatment of addiction, we explored the effect of the HDACi sodium butyrate (NaB) on EtOH-induced behavioral sensitization (EIBS) in DBA/2J mice. We also investigated gene regulations in the striatum of sensitized mice using epigenetic- and signal transduction-related PCR arrays. Methods Mice were injected with saline or EtOH (0.5 to 2.5 g/kg) once a day for 10 days. Mice received NaB (200 to 600 mg/kg) 30 minutes before each injection (prevention protocol) or once daily between days 11 and 16 (reversal protocol). At day 17, brains were removed 30 minutes after a saline or EtOH challenge to assess gene and proteins levels. Results Only the intermediate EtOH doses (1.0 and 2.0 g/kg) were effective in inducing EIBS, and both doses were associated with specific gene regulations in the striatum. The induction of sensitization by 1.0 g/kg (but not 2.0 g/kg) EtOH was dose-dependently prevented or reversed by NaB. Among the 168 studied genes, EIBS blockade was associated with specific gene regulations (bcl-2, bdnf, hdac4, pak1, penk, tacr1, vip…) and changes in brain-derived neurotrophic factor in both striatum and prefrontal cortex. Conclusions These results indicate that EIBS is associated with specific gene regulations in the striatum depending on the EtOH dose and that NaB can be useful in blocking some long-lasting neuro-adaptations to repeated EtOH administrations. Supporting Information Filename Description acer12088-sup-0001-FigS1-S5-TableS1-S4.docWord document, 372 KB Data S1. Materials and methods.Data S2. Results.Fig. S1. Effect of i.p. injections of 600 mg/kg NaB on global nuclear HDAC activity.Fig. S2. Parametric analysis of EIBS.Fig. S3. Effect of 600 mg/kg NaB on 0.5 g/kg-EIBS.Fig. S4. Effects of chronic 1.0 or 2.0 g/kg-EIBS in the absence or presence of 600 mg/kg NaB on blood EtOH and estrogens concentrations.Fig. S5. Effects of chronic 1.0 g/kg or 2.0 g/kg EtOH in the absence or presence of 600 mg/kg NaB on gene expression.Table S1. EtOH 1.0 g/kg and genes involved in transduction pathways: functional classifications of genes regulated by acute treatment and EIBS in the absence or presence of 600 mg/kg NaB.Table S2. EtOH 2.0 g/kg and genes involved in transduction pathways: functional classifications of genes regulated by acute treatment and EIBS in the absence or presence of 600 mg/kg NaB.Table S3. EtOH 1.0 g/kg and genes involved in epigenetic mechanisms: functional classifications of genes regulated by acute treatment and EIBS in the absence or presence of 600 mg/kg NaB.Table S4. EtOH 2.0 g/kg and genes involved in epigenetic mechanisms: functional classifications of genes regulated by acute treatment and EIBS in the absence or presence of 600 mg/kg NaB. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. 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