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Regulation of the Germinal Center Response by MicroRNA-155

2007; American Association for the Advancement of Science; Volume: 316; Issue: 5824 Linguagem: Inglês

10.1126/science.1141229

1095-9203

To‐Ha Thai, Dinis Pedro Calado, Stefano Casola, K. Mark Ansel, Changchun Xiao, Yingzi Xue, Andrew Murphy, David Frendewey, David M. Valenzuela, Jeffery L. Kutok, Marc Schmidt‐Supprian, Nikolaus Rajewsky, George D. Yancopoulos, Anjana Rao, Klaus Rajewsky,

Circular RNAs in diseases

MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.