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Cardiovascular risk and events in polycystic ovary syndrome

2009; Taylor & Francis; Volume: 12; Issue: sup1 Linguagem: Inglês

10.1080/13697130903003842

1473-0804

Enrico Carmina,

Lipid metabolism and disorders

Young women with polycystic ovary syndrome (PCOS) present a high risk for cardiovascular disease because of the presence of abdominal obesity, insulin resistance and androgen excess. In addition, they present with endothelial dysfunction and early signs of atherosclerosis (increased carotid intima-media thickness and increased coronary calcium). However, the evidence of increased cardiovascular events during the postmenopausal age is relatively small, although some recent studies have indicated a slight increase in the severity of cardiovascular disease in women who had PCOS during their fertile age. The discrepancy between cardiovascular risk in young age and postmenopausal cardiovascular events may depend on changes in the risk that happen during the late fertile age or on overestimation of early atherosclerotic signs.