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ent-Kaurene diterpenoids from Isodon oresbius

2004; Elsevier BV; Volume: 65; Issue: 8 Linguagem: Inglês

10.1016/j.phytochem.2004.02.022

1873-3700

Xiang Wei,

Bioactive Natural Diterpenoids Research

Three new ent-kaurene diterpenoids, oreskaurins A–C (1–3), together with ten known ent-kaurene diterpenoids, enmenin monoacetate (4), effusanin E (5), adenolin B (6), maoecrystal G (7), enmelol (8), trichokaurin (9), sodoponin (10), trichorabdal A (11), nodosin (12), enmein (13), and a flavonoid, vitexin (14), were isolated from Isodon oresbius. Their structures were determined by spectroscopic means. Compound 12 showed inhibitory activity toward K562 cells with IC50=1.43 μg/ml.