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A novel and efficient synthesis of pyrimido[4,5-d]pyrimidine-2,4,7-trione and pyrido[2,3-d:6,5-d] dipyrimidine-2,4,6,8-tetrone derivatives

2006; Elsevier BV; Volume: 63; Issue: 8 Linguagem: Inglês

10.1016/j.tet.2006.12.043

1464-5416

Minoo Dabiri, Hamid Arvinnezhad, Hamid Reza Khavasi, Ayoob Bazgir,

Synthesis and biological activity

An efficient and direct procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4,7-trione derivatives has been described under microwave-assisted conditions. Reaction of 6-amino-1,3-dimethyluracil with aromatic aldehydes resulted in the formation of pyrido[2,3-d:6,5-d] dipyrimidine-2,4,6,8-tetrone derivatives.