Dioxopiperazine Alkaloids Produced by the Marine Mangrove Derived Endophytic Fungus Eurotium rubrum
2008; Wiley; Volume: 91; Issue: 10 Linguagem: Inglês
10.1002/hlca.200890202
ISSN1522-2675
AutoresDongli Li, Xiao‐Ming Li, Tie‐Gang Li, Hongyue Dang, Bin‐Gui Wang,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoAbstract Cultivation of the fungal strain Eurotium rubrum , an endophytic fungus that was isolated from the inner tissue of stems of the mangrove plant Hibiscus tiliaceus , resulted in the isolation of two new dioxopiperazine derivatives, namely, dehydrovariecolorin L ( 1 ) and dehydroechinulin ( 2 ), together with eight known dioxopiperazine compounds including variecolorin L ( 3 ), echinulin ( 4 ), isoechinulin A ( 5 ), dihydroxyisoechinulin A ( 6 ), preechinulin ( 7 ), neoechinulin A ( 8 ), neoechinulin E ( 9 ), and cryptoechinuline D ( 10 ). The structures of the isolated compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature. Compounds 1, 2, 9 , and 10 were investigated for their α , α ‐diphenyl‐ β ‐picrylhydrazyl (DPPH) radical‐scavenging activity. In addition, the new compounds, 1 and 2 , were evaluated for their cytotoxic activity against the P‐388, HL‐60, and A549 cell lines.
Referência(s)