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Specific Assay Methods for Droperidol and Fentanyl Citrate in a Pharmaceutical Combination

1968; Elsevier BV; Volume: 57; Issue: 3 Linguagem: Inglês

10.1002/jps.2600570317

1520-6017

Casimir A. Janicki, Ronald J. Brenner, Barbara E. Schwartz,

Pharmacy and Medical Practices

In acid solution, droperidol, 1-{1-[3-(p-fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl}-2-benzimidazolinone, is decomposed to form 4′-fluoro-4-(4-oxopiperidino)butyrophenone and 2-benzimidazolinone. Fentanyl, N-(1-phenethyl-4-piperidyl)propionanilide, is decomposed in acid solution to form 4-anilino-1-(2-phenylethyl)piperidine. A procedure to assay droperidol in the presence of its hydrolysis products, fentanyl, and its hydrolysis product is given. Droperidol is analyzed by its UV absorption after being separated from interfering products. A procedure to assay fentanyl in the presence of its hydrolysis products, droperidol, and its hydrolysis products is given. Droperidol and 4-anilino-1-(2-phenylethyl)-piperidine are separated from fentanyl through the formation of a reineckate derivative and fentanyl is subsequently determined by a methyl orange procedure. Data are presented to show the accuracy and precision of the methods. In acid solution, droperidol, 1-{1-[3-(p-fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl}-2-benzimidazolinone, is decomposed to form 4′-fluoro-4-(4-oxopiperidino)butyrophenone and 2-benzimidazolinone. Fentanyl, N-(1-phenethyl-4-piperidyl)propionanilide, is decomposed in acid solution to form 4-anilino-1-(2-phenylethyl)piperidine. A procedure to assay droperidol in the presence of its hydrolysis products, fentanyl, and its hydrolysis product is given. Droperidol is analyzed by its UV absorption after being separated from interfering products. A procedure to assay fentanyl in the presence of its hydrolysis products, droperidol, and its hydrolysis products is given. Droperidol and 4-anilino-1-(2-phenylethyl)-piperidine are separated from fentanyl through the formation of a reineckate derivative and fentanyl is subsequently determined by a methyl orange procedure. Data are presented to show the accuracy and precision of the methods.