Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies
2015; Elsevier BV; Volume: 125; Issue: 14 Linguagem: Inglês
10.1182/blood-2014-08-595561
ISSN1528-0020
AutoresChristian A. Di Buduo, Lindsay S. Wray, Lorenzo Tozzi, Alessandro Malara, Ying Chen, Chiara E. Ghezzi, Daniel Smoot, Carla Sfara, A. Antonelli, Elise Spedden, Giovanna Bruni, Cristian Staii, Luigi De Marco, Mauro Magnani, David L. Kaplan, Alessandra Balduini,
Tópico(s)Periodontal Regeneration and Treatments
ResumoKey Points Natural silk protein sponge and vascular tubes reproduce human bone marrow niche environments for functional platelet generation ex vivo. Programmable bioengineered model for the investigation and therapeutic targeting of altered platelet formation.
Referência(s)