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The in vivo release of 90Y from cyclic and acyclic ligand-antibody conjugates

1991; Elsevier BV; Volume: 18; Issue: 5 Linguagem: Inglês

10.1016/0883-2897(91)90107-v

1878-2140

A. Harrison, Carole A. Walker, David Parker, Karl J. Jankowski, J. P. Cox, Andrew S. Craig, J. M. Sansom, Nigel R. A. Beeley, Rich Boyce, L Chaplin, Michael A. W. Eaton, APH Farnsworth, Kenneth Millar, Andrew T. Millican, Amanda Randall, Stephen K. Rhind, Dsapd Secher, Alison Turner,

Lymphoma Diagnosis and Treatment

Yttrium binding ligands DOTA, caDTPA and CT-DTPA were each conjugated to monoclonal antibody B72.3, labelled with 90Y and injected into mice in order to assess the in vivo inertness of the antibody-linked 90Y-ligand complexes. Levels of 90Y in femur shafts of the DOTA-B72.3 mice were low, being approximately 7 and 44%, respectively, of levels in the femur shafts of the caDTPA-B72.3 and CT-DTPA-B72.3 treated mice. This finding demonstrates the greater inertness and by implication the greater suitability for immunotherapy of the DOTA-90Y complex.