Preeclampsia, Placenta, Oxidative Stress, and PMCA
2012; Informa; Volume: 31; Issue: 4 Linguagem: Inglês
10.3109/10641955.2012.690058
ISSN1525-6065
AutoresCilia Abad, Teresa Proverbio, Sandy Piñero, Desirée Botana, Delia I. Chiarello, Reinaldo Marı́n, Fulgencio Proverbio,
Tópico(s)Biomarkers in Disease Mechanisms
ResumoThe aim of this study is to summarize the reported evidence on the possible relationship between preeclampsia, placenta, oxidative stress and plasma membrane Ca-ATPase (PMCA) activity, responsible for fine control of intracellular calcium concentration.Literature search was conducted in MEDLINE/PubMed and several unpublished results from our laboratory were included.Lipid peroxidation in placental and red blood cell plasma membranes during preeclampsia and a concomitant diminution of their PMCA activity are described.Uteroplacental hypoperfusion raises lipid peroxidation by-products in the blood plasma that could alter structure and functionality of the cell membranes of the endothelium and several tissues.
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