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MULTIFOCAL RENAL CELL CARCINOMA IN JAPANESE PATIENTS WITH TUMORS WITH MAXIMAL DIAMETERS OF 50 MM. OR LESS

1998; Lippincott Williams & Wilkins; Volume: 159; Issue: 4 Linguagem: Inglês

10.1016/s0022-5347(01)63532-8

1527-3792

Kazuo Gohji, Isao Hara, Akinobu Gotoh, Hiroshi Eto, Hideaki Miyake, Takeki Sugiyama, Hiroshi Okada, Soichi Arakawa, Sadao Kamidono,

Multiple and Secondary Primary Cancers

No AccessJournal of UrologyClinical Urology: Original Articles1 Apr 1998MULTIFOCAL RENAL CELL CARCINOMA IN JAPANESE PATIENTS WITH TUMORS WITH MAXIMAL DIAMETERS OF 50 MM. OR LESS KAZUO GOHJI, ISAO HARA, AKINOBU GOTOH, HIROSHI ETO, HIDEAKI MIYAKE, TAKEKI SUGIYAMA, HIROSHI OKADA, SOICHI ARAKAWA, and SADAO KAMIDONO KAZUO GOHJIKAZUO GOHJI More articles by this author , ISAO HARAISAO HARA More articles by this author , AKINOBU GOTOHAKINOBU GOTOH More articles by this author , HIROSHI ETOHIROSHI ETO More articles by this author , HIDEAKI MIYAKEHIDEAKI MIYAKE More articles by this author , TAKEKI SUGIYAMATAKEKI SUGIYAMA More articles by this author , HIROSHI OKADAHIROSHI OKADA More articles by this author , SOICHI ARAKAWASOICHI ARAKAWA More articles by this author , and SADAO KAMIDONOSADAO KAMIDONO More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)63532-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We determined the risk of local recurrence in 64 Japanese patients a median of 69 years old with renal cell carcinoma who were possible candidates for nephron sparing surgery and who underwent radical nephrectomy. Materials and Methods: A total of 64 kidneys in which tumors 50 mm. or less were resected were prospectively examined pathologically in 3 mm. sections. The incidence of satellite tumors and the relationship between the pathological findings of the primary and satellite tumors were evaluated. Results: Satellite tumors were identified in 10 of the 64 kidneys (15.6%), a rate similar to that reported in the United States. The correlation of histological findings between primary and satellite tumors was 70% for tumor grade. Satellite tumor grade was less than that of the primary lesion in 3 cases. In 60% of the specimens with multifocal renal cancer satellite tumors were within 10 mm. of the margin of the primary tumor. At this distance, if partial nephrectomy had been performed, the satellite lesions would have been missed in 4 of these 10 patients (40%). Of the 10 kidneys with satellite renal tumors 8 (80%) had vascular invasion of the primary tumor. Multiple logistic regression analysis demonstrated that vascular invasion was a significant predictor of multifocality of renal cell carcinoma. Conclusions: Our results suggest that vascular invasion is a risk factor for multifocality in Japanese patients with renal cell carcinoma. Therefore, careful and long-term followup is necessary in patients with renal cell carcinoma who have undergone nephron sparing surgery, especially those with vascular invasion of the primary tumor. References 1 : The results of radical nephrectomy for renal cell carcinoma. J. Urol.1969; 101: 297. Link, Google Scholar 2 : Conservative surgery for renal cell carcinoma: a single-center experience with 100 patients. J. Urol.1989; 141: 835. Link, Google Scholar 3 : Surgical treatment of localized renal cell carcinoma in von Hippel-Lindau's disease. J. Urol.1988; 139: 507. Link, Google Scholar 4 : Renal carcinoma in a solitary kidney. Brit. J. Urol.1990; 67: 248. 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Link, Google Scholar Department of Urology, Kobe University School of Medicine, Chuo-ku, Kobe, Japan.© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byRICHSTONE L, SCHERR D, REUTER V, SNYDER M, RABBANI F, KATTAN M and RUSSO P (2018) Multifocal Renal Cortical Tumors: Frequency, Associated Clinicopathological Features and Impact on SurvivalJournal of Urology, VOL. 171, NO. 2, (615-620), Online publication date: 1-Feb-2004.ZUCCHI A, MEARINI L, MEARINI E, COSTANTINI E, VIVACQUA C and PORENA M (2018) Renal Cell Carcinoma: Histological Findings on Surgical Margins After Nephron Sparing SurgeryJournal of Urology, VOL. 169, NO. 3, (905-908), Online publication date: 1-Mar-2003.SUTHERLAND S, RESNICK M, MACLENNAN G and GOLDMAN H (2018) DOES THE SIZE OF THE SURGICAL MARGIN IN PARTIAL NEPHRECTOMY FOR RENAL CELL CANCER REALLY MATTER?Journal of Urology, VOL. 167, NO. 1, (61-64), Online publication date: 1-Jan-2002.UZZO R and NOVICK A (2018) NEPHRON SPARING SURGERY FOR RENAL TUMORS: INDICATIONS, TECHNIQUES AND OUTCOMESJournal of Urology, VOL. 166, NO. 1, (6-18), Online publication date: 1-Jul-2001.Baltaci S, Orhan D, Soyupek S, Bedük Y, Tulunay Ö and Göğüs O (2018) RE: INFLUENCE OF TUMOR STAGE, SIZE, GRADE, VASCULAR INVOLVEMENT, HISTOLOGICAL CELL TYPE AND HISTOLOGICAL PATTERN ON MULTIFOCALITY OF RENAL CELL CARCINOMAJournal of Urology, VOL. 165, NO. 5, (1643-1643), Online publication date: 1-May-2001.BALTACI S, ORHAN D, SOYUPEK S, BEDÜK Y, TULUNAY Ö and GÖĞÜŞ O (2018) INFLUENCE OF TUMOR STAGE, SIZE, GRADE, VASCULAR INVOLVEMENT, HISTOLOGICAL CELL TYPE AND HISTOLOGICAL PATTERN ON MULTIFOCALITY OF RENAL CELL CARCINOMAJournal of Urology, VOL. 164, NO. 1, (36-39), Online publication date: 1-Jul-2000.BLACK P, FILIPAS D, FICHTNER J, HOHENFELLNER R and THÜROFF J (2018) NEPHRON SPARING SURGERY FOR CENTRAL RENAL TUMORS: EXPERIENCE WITH 33 CASESJournal of Urology, VOL. 163, NO. 3, (737-743), Online publication date: 1-Mar-2000. Volume 159Issue 4April 1998Page: 1144-1147 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.Metrics Author Information KAZUO GOHJI More articles by this author ISAO HARA More articles by this author AKINOBU GOTOH More articles by this author HIROSHI ETO More articles by this author HIDEAKI MIYAKE More articles by this author TAKEKI SUGIYAMA More articles by this author HIROSHI OKADA More articles by this author SOICHI ARAKAWA More articles by this author SADAO KAMIDONO More articles by this author Expand All Advertisement PDF downloadLoading ...