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Circulating activated (DR-positive) T lymphocytes in a patient with autoeczematization

1986; Elsevier BV; Volume: 14; Issue: 6 Linguagem: Inglês

10.1016/s0190-9622(86)70129-1

1097-6787

Michael J. Cunningham, John J. Zone, Marta J. Petersen, Jon A. Green,

T-cell and B-cell Immunology

A patient with classical hypostatic dermatitis-related autoeczematization was found to have an elevated ratio of helper to suppressor T lymphocytes and increased circulating activated T cells in the absence of detectable levels of circulating interferon. Despite the high levels of activated T cells, peripheral blood mononuclear leukocytes did not produce interferon spontaneously in culture. These findings suggest that autoeczematization is a form of cell mediated autoimmunity and that activated T cells and interferon production may be unrelated in vivo.