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The mRNA assembly line: transcription and processing machines in the same factory

2002; Elsevier BV; Volume: 14; Issue: 3 Linguagem: Inglês

10.1016/s0955-0674(02)00333-2

1879-0410

David L. Bentley,

RNA modifications and cancer

Processing of RNA precursors to their mature form often occurs co-transcriptionally. Consequently, the ternary complex of DNA template, RNA polymerase and nascent RNA chain is the physiological substrate for factors that modify the nascent RNA by capping, splicing and cleavage/polyadenylation. mRNA production is thought to occur within a 'factory' that contains the RNA polymerase II transcription machine and the processing machines. Newly discovered protein–protein contacts between RNA polymerase and factors that process mRNA precursors are beginning to illuminate how the 'mRNA factory' works.