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Sch S0673 and Sch 50676, Two Novel Antitumor Fungal Metabolites.

1995; Springer Nature; Volume: 48; Issue: 4 Linguagem: Inglês

10.7164/antibiotics.48.329

1881-1469

Min Chu, Imbi Truumees, Mahesh Patel, C H Blood, Pradip R. Das, Mohindar S. Puar,

Fungal Biology and Applications

Several biologically active keto-epoxides, containing a unique decalone with a spiro-ketal linkage through a naphthalene moiety, have been isolated from various fungi.1 ~7) In the course of our continuing search for new antitumor agents, two novel minor metabolites, Sch 50673 (1) and Sch 50676 (2) were discovered from the fungus, Nattrassia mangiferae (ATCC74078), in a large scale fermentation broth.This paper describes the fermentation, isolation, structure elucidation and bio-activity of these two secondary fungal metabolites.The fungus was isolated from a substrate collected along the road between Cuilapa and Chiquimullilla, Guatemala.The area is arid and approximately 300 meters in elevation.The strain itself was isolated from dead leaves about one meter above ground8) and identified as N. mangiferae which was originally