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A global map of the Leishmania major genome: prelude to genomic sequencing

1997; Oxford University Press; Volume: 91; Issue: 2 Linguagem: Inglês

10.1016/s0035-9203(97)90188-7

1878-3503

Alasdair Ivens, Deborah F. Smith,

Enzyme Production and Characterization

In 1994, the World Health Organization (TDR) launched a new strategic initiative in parasite genome analysis, establishing international genome networks for filariae, Schistosoma, Leishmania, Trypanosoma brucei and T. cruzi. For Leishmania, a number of different but complementary approaches have been adopted by members of the Leishmania Genome Network. Our laboratory has been using cosmid clone fingerprinting to produce a physical map of the genome. Progress towards the completion of an integrated physical and biological map of L. major, and the preparations for genomic sequencing, are described.