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HLA-E–dependent Presentation of Mtb-derived Antigen to Human CD8+ T Cells

2002; Rockefeller University Press; Volume: 196; Issue: 11 Linguagem: Inglês

10.1084/jem.20020609

1540-9538

Amy S. Heinzel, Jeff E. Grotzke, Rebecca A. Lines, Deborah A. Lewinsohn, Andria L. McNabb, Daniel N. Streblow, Véronique M. Braud, Heather Grieser, John T. Belisle, David Lewinsohn,

T-cell and B-cell Immunology

Previous studies in mice and humans have suggested an important role for CD8+ T cells in host defense to Mtb. Recently, we have described human, Mtb-specific CD8+ cells that are neither HLA-A, B, or C nor group 1 CD1 restricted, and have found that these cells comprise the dominant CD8+ T cell response in latently infected individuals. In this report, three independent methods are used to demonstrate the ability of these cells to recognize Mtb-derived antigen in the context of the monomorphic HLA-E molecule. This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis.