Portal de Periódicos da CAPES

Effects of Ginkgo biloba Extract on Inflammatory Mediators (SOD, MDA, TNF‐ α , NF‐ κ Bp65, IL‐6) in TNBS‐Induced Colitis in Rats

2006; Hindawi Publishing Corporation; Volume: 2006; Issue: 1 Linguagem: Inglês

10.1155/mi/2006/92642

1466-1861

Yanhong Zhou, Jie‐Ping Yu, Yifei Liu, Xiao-Jun Teng, Mei Jian Ming, Peng Lv, Ping An, Shiquan Liu, Honggang Yu,

Nuclear Receptors and Signaling

Inflammatory mediators play a criticial role in ulcerative colitis immune and inflammatory processes. The aim of the study was to investigate the effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF‐ α , NF‐ κ Bp65, IL‐6) in TNBS‐induced colitis in rats. Colitis in rats was induced by colonic administration with 2,4,6‐trinitrobenzene sulfonic acid (TNBS, 150 mg/kg). EGB in doses of (50, 100, 200 mg/kg) was administered for 4 weeks to protect colitis. The results showed that EGB could significantly ameliorate macroscopic and histological damage, evidently elevate the activities of SOD and reduce the contents of MDA, inhibit the protein and mRNA expressions of TNF‐ α , NF‐ κ Bp65, and IL‐6 in the colon tissues of experimental colitis in a dose‐dependent manner compared with the model group. We concluded that the probable mechanisms of EGB ameliorated inflammatory injury in TNBS‐induced colitis in rats by its modulation of inflammatory mediators and antioxidation.