On the Derivatization of Drugs Using 1-Nitroso-2-naphthol, 4-aminoantipyrine and 2,6-Dihaloquinone Chlorimides
1992; Taylor & Francis; Volume: 25; Issue: 11 Linguagem: Inglês
10.1080/00032719208020075
ISSN1532-236X
AutoresM.C. García‐Álvarez‐Coque, Guillermo Ramis‐Ramos, Josep Esteve‐Romero,
Tópico(s)Synthesis and Characterization of Heterocyclic Compounds
ResumoAbstract Coupling of 1-nitroso-2-naphthol (1N2N), 4-aminoantipyrine (4-AAP), 2,6-dichloroquinone chlorimide (DCQC) and 2,6-dibromoquinone chlorimide (DBQC) with several bioactive substances, including adrenergics and β-blockers, was tried in water, and in sodiur. dodecylsulphate (SDS), Triton X-100 and N-cetylpyridinium chloride micellar media. In SDS micellar solutions, not only phenolic drugs, but also arylalkyl ethers with the 2 and 3 positions adjacent to the ether group free, coupled with 1N2N. Only phenolic drugs could be derivatized with the other reagents tried; the derivatives bound to the micelles, the absorption bands showing important shifts together with a sensitivity increase.
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