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Cycloheximide-producing and Fungicidin-producing Mutants of Streptomyces noursei

1965; Microbiology Society; Volume: 39; Issue: 3 Linguagem: Inglês

10.1099/00221287-39-3-305

2059-9323

Libuše Doležilová, J. Spížek, M. Vondráček, F. Palečková, З. Ванек,

Synthetic Organic Chemistry Methods

SUMMARY Streptomyces noursei strain 52/152 produced compounds of the cyclo-heximide series and fungicidin. On the contrary its mutant strain 54/465 did not produce any compound of the cycloheximide series, and as compared with strain 52/152 produced about double the amount of fungicidin. This strain 52/152 was also insensitive to additions to the cultivation medium of fungicidin up to a concentration of 20,000 units/ml. In the strains studied, a direct proportionality was observed between fungicidin production and sensitivity to it. The interrelation of their production is discussed from the viewpoint of a common precursor for fungicidin and cycloheximide (malonyl-coenzyme A).