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Guttate psoriasis induced by infliximab in a child with Crohnʼs disease

2008; Oxford University Press; Volume: 14; Issue: 10 Linguagem: Inglês

10.1002/ibd.20450

1536-4844

Marta Costa‐Romero, Pablo Coto‐Segura, Sonsoles Suarez-Saavedra, E. Ramos-Polo, Jorge Santos‐Juanes,

Immunodeficiency and Autoimmune Disorders

strong clinical significance for the cause and the mechanism of Crohn's disease.More and more evidence has suggested that gut bacteria play a critical role in the development of inflammatory bowel disease, and Crohn's disease seems to develop in the intestine largely as a result of aberrant interaction of gut bacteria and their components with the host.If this is true, we would have to answer how Crohn's disease with the same nature occurred in the mouth and esophagus, where the amount of bacteria is very limited.Lesions of the intestine can usually be found at the same time or eventually show up in patients with "Crohn's disease of the esophagus or the mouth." 5,6 It seems that lesions of the esophagus and mouth are more likely to be manifestations of intestinal Crohn's disease rather to have originated locally.If this is the case, the lesions of the esophagus and mouth should probably be called oral or esophageal manifestations (or complications) of Crohn's disease rather Crohn's disease of the esophagus or the mouth, just like the uveitis in Crohn's patients would be better called a manifestation of Crohn's disease in the eye rather Crohn's disease of the eye.Saying that Crohn's disease can occur anywhere in the digestive tract seems to be a convenient but potentially misleading statement.