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Fetal Effects of Maternal Streptozotocin-Diabetes

1974; Oxford University Press; Volume: 94; Issue: 5 Linguagem: Inglês

10.1210/endo-94-5-1247

1945-7170

Roy M. Pitkin, Dianna E. Van Orden,

Diabetes and associated disorders

A chronic diabetic-like state was induced in nonpregnant rats by iv administration of streptozotocin (STZ) 40 mg/kg. The animals were bred and then killed on day 22 of pregnancy. Fetal and placental weights, plasma glucose and immunoreactive insulin (IRI) levels, and pancreatic IRI and histology were studied. Rats exhibiting minimal glucosuria during pregnancy produced fetuses which were slightly (but not significantly) larger than controls while rats with more marked glucosuria had fetuses significantly smaller, and placentas significantly larger, than controls. Maternal hyperglycemia with STZ treatment was associated with hyperglycemia and hyperinsulinemia in the fetus. While fetal pancreatic IRI was not significantly different in treated and control subjects, histologic evidence of hyperfunction of the fetal pancreatic islets, roughly proportional in degree to the severity of the maternal diabetic-like state, was found. These results are consistent with the hyperglycemia-hyperinsulinemia theory of fetal pathophysiology in maternal diabetes mellitus (Endocrinology94: 1247, 1974)