Blood‐retina barrier permeability in diabetes during acute ACE‐inhibition
1991; Wiley; Volume: 69; Issue: 5 Linguagem: Inglês
10.1111/j.1755-3768.1991.tb04843.x
ISSN1755-3768
AutoresC. Engler, Hans‐Henrik Parving, Elisabeth R. Mathiesen, Michael Larsen, Henrik Lund‐Andersen,
Tópico(s)Blood Pressure and Hypertension Studies
ResumoAbstract We assessed the acute effect of ACE‐inhibition (captopril) on blood‐retina barrier (BRB) permeability in 10 hypertensive insulin‐dependent diabetic patients with background retinopathy in a double‐masked placebo controlled cross‐over study. All patients underwent ophthalmological examination, fundus photography, fluorescein angiography, vitreous fluorometry, and continuous blood pressure recording within 3 h of the drug/placebo administration. The decrease in mean arterial blood presure, from placebo treatment 149/92 ± 17/7 to captopril treatment 132/83±14/7 mmHg (mean ± sd), P < 0.01 was not accompanied by a significant decrease in BRB permeability, which was 2.51 (1.24–9.15) with placebo and 3.02 (1.25–13.93) ± 10 ‐7 cm/s during captopril treatment (geometric mean and range), NS. Our study suggests that abnormal leakage through the BRB in hypertensive insulin‐dependent diabetic patients with background retinopathy is caused predominantly by structural changes in the retinal vessels whereas hydrostatic forces play a minor role.
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