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Natural-born killers unleashed

2014; Nature Portfolio; Volume: 510; Issue: 7505 Linguagem: Inglês

10.1038/nature13503

ISSN

1476-4687

Autores

Emilio Hirsch, Francesco Novelli,

Tópico(s)

Immune cells in cancer

Resumo

The finding that phosphoinositide-3-OH kinase δ restrains the antitumour immune response by promoting the action of suppressive immune cells may broaden the applicability of drugs targeting this enzyme to multiple cancers. See Letter p.407 This paper shows that the p110δ isoform of phosphoinositide-3-OH kinase (PI(3)K) is critically required for the immunosuppressive function of regulatory T (Treg) cells. Inactivation of p110δ in Treg cells leads to enhanced cytotoxic T-cell function and restricts tumour growth and metastasis in a variety of mouse tumour models. This finding identifies p110δ as a druggable kinase target for which inhibition boosts the cancer-suppressive potential of the immune system.

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