Portal de Periódicos da CAPES

Enterovirus 71 encephalitis: a new vaccine on the horizon?

2013; Elsevier BV; Volume: 381; Issue: 9871 Linguagem: Inglês

10.1016/s0140-6736(13)60286-x

1474-547X

Mark A. Pallansch, M. Steven Oberste,

Whipple's Disease and Interleukins

Since its discovery in 1969, enterovirus 71 (EV71) has been associated with outbreaks of severe neurological disease and mild hand, foot, and mouth disease. 1 Solomon T Lewthwaite P Perera D Cardosa MJ McMinn P Ooi MH Virology, epidemiology, pathogenesis, and control of enterovirus 71. Lancet Infect Dis. 2010; 10: 778-790 Summary Full Text Full Text PDF PubMed Scopus (956) Google Scholar The virus circulates worldwide and caused several outbreaks of poliomyelitis-like paralysis and brainstem encephalitis in eastern Europe during the 1970s, with few associated outbreaks of hand, foot, and mouth disease. Yet in Europe and North America, EV71 is a common cause (as are several other enteroviruses) of hand, foot, and mouth disease—a common illness of young children—although few cases are regarded as serious in these regions. Immunogenicity and safety of an enterovirus 71 vaccine in healthy Chinese children and infants: a randomised, double-blind, placebo-controlled phase 2 clinical trialTaking immunogenicity, safety, and production capacity into account, the 320 U alum-adjuvant formulation of the EV71 vaccine is probably the best possible formulation for phase 3 trials. Full-Text PDF