Produção Nacional
Revisado por pares
Seasonal and biological variations of Epidendrum mosenii : quantification of 24-methylenecycloartanol using gas chromatography
2007; Taylor & Francis; Volume: 21; Issue: 11 Linguagem: Inglês
10.1080/14786410701371553
ISSN1478-6427
AutoresPatrícia Walter Rosa, Marina da Silva Machado, Fátima de Campos Buzzi, Rivaldo Niero, Franco Delle Monachè, Valdir Cechinel Filho,
Tópico(s)Phytochemistry and Biological Activities
ResumoEpidendrum mosenii is a Brazilian medicinal plant, traditionally used to treat infective and dolorous processes. The present article reports a comparative study of the chemical and pharmacological aspects of different parts and seasons of this plant. The results demonstrate that 24-methylenecycloartanol (1), one of the main active principles present in this plant, is located practically in all the parts and during all seasons, but it is much more concentrated in the stems when collected in spring and summer. The pharmacological results indicate that dichloromethane extracts collected in spring and summer were the most active when evaluated against the writhing test in mice, being several times more potent than some reference drugs used as comparison. Together, the results strongly suggest that the antinociceptive effect of E. mosenii is related, at least in part, to the presence of compound 1, and this finding could be useful for quality control of phytopreparations based on this plant.
Referência(s)