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Preoperative estimation of asialoglycoprotein receptor expression in the remnant liver from CT/ 99m Tc‐GSA SPECT fusion images correlates well with postoperative liver function parameters

2010; Wiley; Volume: 17; Issue: 5 Linguagem: Inglês

10.1007/s00534-010-0264-6

1868-6982

Yuji Iimuro, T Kashiwagi, Junichi Yamanaka, Tadamichi Hirano, Shinichi Saito, Takaaki Sugimoto, Shinichiro Watanabe, Nobukazu Kuroda, Toshihiro Okada, Yasukane Asano, Naoki Uyama, Jiro Fujimoto,

Liver Disease Diagnosis and Treatment

Abstract Background Accurate preoperative estimation of remnant liver function is critically important for hepatic surgery, and the expression of asialoglycoprotein receptors (ASGPR) is associated with hepatic function. Methods Thirty‐two patients with hepatocellular carcinoma who underwent surgical resection were studied. To estimate the expression of ASGPR in the remnant liver, simulated surgery was performed on fusion images that combined data from 99m technetium‐galactosyl human serum albumin ( 99m Tc‐GSA)/single photon emission computed tomography (SPECT) and computed tomography (CT) scanning. The liver uptake ratio (LUR) of 99m Tc‐GSA and the functional liver volume (FLV) in the remnant liver were predicted and were compared with postoperative liver function parameters. Results The LUR of 99m Tc‐GSA was strongly correlated with the extent of hepatic ASGPR expression ( r = 0.944, p = 5.01 × 10 −16 ), being confirmed to be a reliable parameter for the evaluation of liver function. The estimated remnant LUR, but not the estimated remnant FLV, was significantly correlated with postoperative liver function parameters, such as serum total bilirubin ( r = −0.430, p < 0.05), prothrombin activity ( r = 0.515, p < 0.01), and serum cholinesterase activity ( r = 0.546, p < 0.01) at 1 week. Conclusion Preoperative estimation of the extent of ASGPR expression in the remnant liver on CT/GSA‐SPECT fusion images correlated well with postoperative liver function parameters, suggesting its usefulness for surgical decisions.