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Ultrastructural analysis of primary endings in deaf white cats: Morphologic alterations in endbulbs of held

1997; Wiley; Volume: 385; Issue: 2 Linguagem: Inglês

10.1002/(sici)1096-9861(19970825)385

1096-9861

David K. Ryugo, Tan Pongstaporn, David M. Huchton, John K. Niparko,

Neural dynamics and brain function

Journal of Comparative NeurologyVolume 385, Issue 2 p. 230-244 Ultrastructural analysis of primary endings in deaf white cats: Morphologic alterations in endbulbs of held D.K. Ryugo, Corresponding Author D.K. Ryugo [email protected] Department of Otolaryngology-Head and Neck Surgery, Center for Hearing Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Neuroscience, Center for Hearing Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205Center for Hearing Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205Search for more papers by this authorT. Pongstaporn, T. Pongstaporn Department of Otolaryngology-Head and Neck Surgery, Center for Hearing Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205Search for more papers by this authorD.M. Huchton, D.M. Huchton Department of Otolaryngology-Head and Neck Surgery, Center for Hearing Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205Search for more papers by this authorJ.K. Niparko, J.K. Niparko Department of Otolaryngology-Head and Neck Surgery, Center for Hearing Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205Search for more papers by this author D.K. Ryugo, Corresponding Author D.K. Ryugo [email protected] Department of Otolaryngology-Head and Neck Surgery, Center for Hearing Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Neuroscience, Center for Hearing Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205Center for Hearing Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205Search for more papers by this authorT. Pongstaporn, T. Pongstaporn Department of Otolaryngology-Head and Neck Surgery, Center for Hearing Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205Search for more papers by this authorD.M. Huchton, D.M. Huchton Department of Otolaryngology-Head and Neck Surgery, Center for Hearing Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205Search for more papers by this authorJ.K. Niparko, J.K. Niparko Department of Otolaryngology-Head and Neck Surgery, Center for Hearing Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205Search for more papers by this author First published: 06 December 1998 https://doi.org/10.1002/(SICI)1096-9861(19970825)385:2 3.0.CO;2-2Citations: 108AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Changes in structure and function of the auditory system can be produced by experimentally manipulating the sensory environment, and especially dramatic effects result from deprivation procedures. An alternative deprivation strategy utilizes naturally occurring lesions. The congenitally deaf white cat represents an animal model of sensory deprivation because it mimics a form of human deafness called the Scheibe deformity and permits studies of how central neurons react to early-onset cochlear degeneration. We studied the synaptic characteristics of the endbulb of Held, a prominent auditory nerve terminal in the cochlear nucleus. Endbulbs arise from the ascending branch of the auditory nerve fiber and contact the cell body of spherical bushy cells. After 6 months, endbulbs of deaf white cats exhibit alterations in structure that are clearly distinguishable from those of normal hearing cats, including a diminution in terminal branching, a reduction in synaptic vesicle density, structural abnormalities in mitochondria, thickening of the pre- and postsynaptic densities, and enlargement of synapse size. 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