Results of a thymic epithelial transplant in a child with Wiskott-Aldrich syndrome and central nervous system lymphoma
1981; Academic Press; Volume: 18; Issue: 1 Linguagem: Inglês
10.1016/0090-1229(81)90015-5
ISSN1090-2341
AutoresJohn J. Hutter, James F. Jones,
Tópico(s)Receptor Mechanisms and Signaling
ResumoA 3-year-old boy with Wiskott-Aldrich syndrome who was treated with transfer factor since early infancy developed primary central nervous system lymphoma. After an initial favorable response to radiation therapy, the lymphoma recurred but improved after chemotherapy. A thymic epithelial transplant was performed that resulted in clinical improvement in his eczema, a decrease in serum IgE, and an increase in E-rosette-positive cells in the peripheral blood. The transplant produced no improvement in antibody response to polysaccharide antigen, skin test reactivity, or in the level of thrombocytopenia. The duration of remission of the lymphoma after treatment with chemotherapy plus thymic epithelial transplantation was greater than that achieved with radiation therapy alone.
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