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A Phenylboronate‐Functionalized Polyion Complex Micelle for ATP‐Triggered Release of siRNA

2012; Wiley; Volume: 51; Issue: 43 Linguagem: Inglês

10.1002/anie.201203360

1521-3773

Mitsuru Naito, Takehiko Ishii, Akira Matsumoto, Kanjiro Miyata, Yuji Miyahara, Kazunori Kataoka,

Nanoparticle-Based Drug Delivery

Angewandte Chemie International EditionVolume 51, Issue 43 p. 10751-10755 Communication A Phenylboronate-Functionalized Polyion Complex Micelle for ATP-Triggered Release of siRNA† Mitsuru Naito, Mitsuru Naito Department of Materials Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan) http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this authorDr. Takehiko Ishii, Dr. Takehiko Ishii Department of Bioengineering, The University of Tokyo (Japan)Search for more papers by this authorDr. Akira Matsumoto, Dr. Akira Matsumoto Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (Japan)Search for more papers by this authorDr. Kanjiro Miyata, Dr. Kanjiro Miyata Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, The University of Tokyo (Japan)Search for more papers by this authorDr. Yuji Miyahara, Dr. Yuji Miyahara Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (Japan)Search for more papers by this authorDr. Kazunori Kataoka, Corresponding Author Dr. Kazunori Kataoka kataoka@bmw.t.u-tokyo.ac.jp Department of Materials Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan) http://www.bmw.t.u-tokyo.ac.jp/Department of Materials Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan) http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this author Mitsuru Naito, Mitsuru Naito Department of Materials Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan) http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this authorDr. Takehiko Ishii, Dr. Takehiko Ishii Department of Bioengineering, The University of Tokyo (Japan)Search for more papers by this authorDr. Akira Matsumoto, Dr. Akira Matsumoto Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (Japan)Search for more papers by this authorDr. Kanjiro Miyata, Dr. Kanjiro Miyata Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, The University of Tokyo (Japan)Search for more papers by this authorDr. Yuji Miyahara, Dr. Yuji Miyahara Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (Japan)Search for more papers by this authorDr. Kazunori Kataoka, Corresponding Author Dr. Kazunori Kataoka kataoka@bmw.t.u-tokyo.ac.jp Department of Materials Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan) http://www.bmw.t.u-tokyo.ac.jp/Department of Materials Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan) http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this author First published: 21 August 2012 https://doi.org/10.1002/anie.201203360Citations: 167 † This research is supported by the Japan Society for the Promotion of Science (JSPS) through the “Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program).” Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract PIC-ing a winner: siRNA encapsulated by a phenylboronate-functionalized polyion complex (PIC) micelle shows binding between the phenylboronate and the 3′ ribose of the siRNA (see scheme), stabilizing the complex under conditions equivalent to the extracellular environment. This complex is disrupted in response to addition of ATP, at a concentration comparable to that inside cells. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201203360_sm_miscellaneous_information.pdf559.1 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume51, Issue43October 22, 2012Pages 10751-10755 RelatedInformation