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A concise stereocontrolled total synthesis of (+)-estrone

1992; Elsevier BV; Volume: 33; Issue: 14 Linguagem: Inglês

10.1016/s0040-4039(00)74175-x

1873-3581

Seiichi Takano, Minoru Moriya, Kunio Ogasawara,

Marine Sponges and Natural Products

(+)-Estrone (1) has been synthesized in diastereo- and regioselective manners in six steps in 28% overall yield (38% based on the consumed material) starting from (−)-dicyclopentadienone (2) by employing a Diels-Alder cycloaddition-cycloreversion as the key step.