Fenoprofen: Inhibitor of prostaglandin synthesis
1974; Elsevier BV; Volume: 6; Issue: 2 Linguagem: Inglês
10.1016/0090-6980(74)90022-7
ISSN1878-416X
AutoresPeter P.K. Ho, Michail A. Esterman,
Tópico(s)Eicosanoids and Hypertension Pharmacology
ResumoFenoprofen, an anti-inflammatory agent, is a potent inhibitor of prostaglandin synthesis at physiological substrate concentration. I50's of 1 μM to 100 μM were obtained when the concentration of arachidonate was increased from 1 μM to 82 μM. In contrast, a small change in I50 was observed with indomethacin. Kinetic studies indicated that inhibition by fenoprofen was competitive while that of indomethacin was non-competitive.
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