Aquaporin-4 Autoantibodies in a Paraneoplastic Context
2008; American Medical Association; Volume: 65; Issue: 5 Linguagem: Inglês
10.1001/archneur.65.5.629
ISSN1538-3687
AutoresSean J. Pittock, Vanda A. Lennon,
Tópico(s)Protein Tyrosine Phosphatases
ResumoBackground:The neuromyelitis optica IgG autoantibody (NMO-IgG) is a validated biomarker for NMO and an emerging spectrum of inflammatory central nervous system-demyelinating disorders.Its antigen is the astrocytic water channel aquaporin-4; NMO-IgG has not been described in a cancer context.Objectives: To report (1) neurologic and oncologic correlates for patients incidentally identified as NMO-IgG seropositive in a blinded evaluation for paraneoplastic autoantibodies and (2) the frequency of cancer in NMO-IgG-seropositive patients.
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