Pain relief by somatostatin in attacks of cluster headache
1984; Lippincott Williams & Wilkins; Volume: 18; Issue: 4 Linguagem: Inglês
10.1016/0304-3959(84)90048-4
ISSN1872-6623
AutoresF Sicuteri, Pierangelo Geppetti, Simone Marabini, F. Lembeck,
Tópico(s)Pain Mechanisms and Treatments
ResumoThe pain relieving effect of somatostatin treatment during 72 attacks of cluster headache in 8 male patients was compared to treatment with ergotamine or placebo in a double-blind study. Infusion of somatostatin (25 μg/min for 20 min i.v.) reduced the maximal pain intensity and the duration of pain significantly compared to placebo treatment, and to a degree comparable to ergotamine tartrate treatment (250 μg i.m.). The results obtained provide new information concerning the possible mechanism of cluster headache attacks and suggest a new therapeutic approach.
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