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Association of different tumor necrosis factor α promoter allele frequencies with ankylosing spondylitis in HLA-B27 positive individuals

1998; Wiley; Volume: 41; Issue: 8 Linguagem: Inglês

10.1002/1529-0131(199808)41

1529-0131

Thomas Höhler, Thomas Schäper, Peter M. Schneider, Karl‐H. Meyer zum Büschenfelde, E. Märker‐Hermann,

Psoriasis: Treatment and Pathogenesis

Arthritis & RheumatismVolume 41, Issue 8 p. 1489-1492 Clinical ScienceFree to Read Association of different tumor necrosis factor α promoter allele frequencies with ankylosing spondylitis in HLA-B27 positive individuals Thomas Höhler, Corresponding Author Thomas Höhler Johannes Gutenberg Universität Mainz, Mainz, GermanyI. Medizinische Klinik und Poliklinik, Johannes Gutenberg Universität Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany.Search for more papers by this authorThomas Schäper, Thomas Schäper Johannes Gutenberg Universität Mainz, Mainz, Germany This work contains essential portions of Mr. Schäper's doctoral thesis.Search for more papers by this authorPeter M. Schneider, Peter M. Schneider Johannes Gutenberg Universität Mainz, Mainz, GermanySearch for more papers by this authorKarl-H. Meyer zum Büschenfelde, Karl-H. Meyer zum Büschenfelde Johannes Gutenberg Universität Mainz, Mainz, GermanySearch for more papers by this authorElisabeth Märker-Hermann, Elisabeth Märker-Hermann Johannes Gutenberg Universität Mainz, Mainz, GermanySearch for more papers by this author Thomas Höhler, Corresponding Author Thomas Höhler Johannes Gutenberg Universität Mainz, Mainz, GermanyI. Medizinische Klinik und Poliklinik, Johannes Gutenberg Universität Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany.Search for more papers by this authorThomas Schäper, Thomas Schäper Johannes Gutenberg Universität Mainz, Mainz, Germany This work contains essential portions of Mr. Schäper's doctoral thesis.Search for more papers by this authorPeter M. Schneider, Peter M. Schneider Johannes Gutenberg Universität Mainz, Mainz, GermanySearch for more papers by this authorKarl-H. Meyer zum Büschenfelde, Karl-H. Meyer zum Büschenfelde Johannes Gutenberg Universität Mainz, Mainz, GermanySearch for more papers by this authorElisabeth Märker-Hermann, Elisabeth Märker-Hermann Johannes Gutenberg Universität Mainz, Mainz, GermanySearch for more papers by this author First published: 28 May 2004 https://doi.org/10.1002/1529-0131(199808)41:8 3.0.CO;2-5Citations: 64 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Objective To investigate the potential association of tumor necrosis factor α (TNFα) promoter alleles with ankylosing spondylitis. Methods DNA from 141 HLA-B27 positive Caucasian patients with ankylosing spondylitis and 46 B27-positive and 99 B27-negative healthy Caucasian controls was investigated by polymerase chain reaction amplification of the TNFα promoter region and subsequent dot-blot analysis with allele-specific oligonucleotides. Results There was a significant decrease in the promoter alleles TNF-238.2 and TNF-308.2 in the ankylosing spondylitis group (266 wild-type alleles, 16 variant alleles) compared with the B27-positive (75 wild-type promoter alleles, 17 variant alleles; P < 0.0004) and the B27-negative (159 wild-type promoter alleles, 39 variant alleles; P < 0.00001) control groups. Positivity for the variant promoter alleles conferred protection and a relative risk of 0.3 to B27-positive individuals. Conclusion These data indicate that allelic variations in the TNFα promoter influence disease susceptibility in HLA-B27 positive individuals. This protective effect of variant promoter alleles could be related to differences in TNFα production or could reflect the association of different B27 haplotypes with ankylosing spondylitis. Supporting Information View article in HTML via Journals@Ovid Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1 Brewerton DA, Hart FD, Nichols A, Caffrey M, James DCO, Sturrock RD. Ankylosing spondylitis and HL-A27. Lancet 1973; 1: 904–7. 2 Van der Linden S, van der Heijde DM. 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