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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Death or survival with major morbidity in VLBW infants born at Brazilian neonatal research network centers

2015; Informa; Volume: 29; Issue: 6 Linguagem: Inglês

10.3109/14767058.2015.1031740

ISSN

1476-7058

Autores

Ruth Guinsburg, Maria Fernanda Branco de Almeida, Junia Sampel de Castro, Rita C. Silveira, Jamil Pedro de Siqueira Caldas, Humberto Holmer Fiori, Marynéa Silva do Vale, Vânia Olivetti Steffen Abdallah, Laura Emilia Monteiro Bigélli Cardoso, Navantino Alves Filho, Maria Elisabeth Lopes Moreira, Ana Lúcia Acquesta, L. Ferrari, Maria Regina Bentlin, Paulyne Stadler Venzon, Walusa Assad Gonçalves‐Ferri, Jucille Meneses, Edna Maria de Albuquerque Diniz, Dulce M. Zanardi, Cristina Nunes dos Santos, José Luiz Muniz Bandeira Duarte, Maria Albertina Santiago Rego,

Tópico(s)

Neonatal Health and Biochemistry

Resumo

To analyze unfavorable outcomes at hospital discharge of preterm infants born at Brazilian public university centers.Prospective cohort of 2646 inborn infants with gestational age 23-33 weeks and birth weight 400-1499 g, without malformations, born at 20 centers in 2012-2013. Unfavorable outcome was defined as in-hospital death or survival at hospital discharge with ≥1 major morbidities: bronchopulmonary dysplasia (BPD) at 36 corrected weeks, intraventricular hemorrhage (IVH) grades 3-4, periventricular leukomalacia (PVL) or surgically treated retinopathy of prematurity (ROP).Among 2646 infants, 1390 (53%) either died or survived with major morbidities: 793 (30%) died; 497 (19%) had BPD; 358 (13%) had IVH 3-4 or PVL; and 84 (3%) had ROP. Logistic regression adjusted by center showed association of unfavorable outcome with: antenatal steroids (OR 0.70; 95%CI 0.55-0.88), C-section (0.72; 0.58-0.90), gestational age <30 (4.00; 3.16-5.07), being male (1.44; 1.19-1.75), small for gestational age (2.19; 1.72-2.78), 5th-min Apgar <7 (3.89; 2.88-5.26), temperature at NICU admission <36.0 °C (1.42; 1.15-1.76), respiratory distress syndrome (3.87; 2.99-5.01), proven late sepsis (1.33; 1.05-1.69), necrotizing enterocolitis (3.10; 2.09-4.60) and patent ductus arteriosus (1.69; 1.37-2.09).More than half of the VLBW infants born at public university level 3 Brazilian hospitals either die or survive with major morbidities.

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