Evolution of MHC class I genes in two ancient fish, paddlefish ( Polyodon spathula ) and Chinese sturgeon ( Acipenser sinensis )
2010; Wiley; Volume: 584; Issue: 15 Linguagem: Inglês
10.1016/j.febslet.2010.05.065
ISSN1873-3468
AutoresDengqiang Wang, Lei Zhong, Qiwei Wei, Xiaoni Gan, Shunping He,
Tópico(s)Immune Cell Function and Interaction
ResumoHere we present the first isolation of major histocompatibility complex (MHC) class I genes from two ancient fish, paddlefish ( Polyodon spathula ) and Chinese sturgeon ( Acipenser sinensis ). Seventeen sequences obtained showed high polymorphism and positive natural selection with d N / d S > 1. Evolutionary relationships revealed that sequences from paddlefish and Chinese sturgeon distinguished from other vertebrate class I and had an intermingling of alleles, which indicates that Acipenseriformes have a common ancestral gene of class I and a trans‐species polymorphism across Acipenseriformes. We also found clear evidence of recombination among class I genes of paddlefish and Chinese sturgeon.
Referência(s)