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BIBTEX RIS

The Recombinant BCG Δ ureC::hly Vaccine Targets the AIM2 Inflammasome to Induce Autophagy and Inflammation

2014; Oxford University Press; Volume: 211; Issue: 11 Linguagem: Inglês

10.1093/infdis/jiu675

ISSN

1537-6613

Autores

Hiroyuki Saiga, Natalie E. Nieuwenhuizen, Martin Gengenbacher, Anne‐Britta Koehler, Stefanie Schuerer, Pedro Moura‐Alves, Ina Wagner, Hans‐Joachim Mollenkopf, Anca Dorhoi, Stefan H. E. Kaufmann,

Tópico(s)

interferon and immune responses

Resumo

Background. The recombinant BCG ΔureC::hly (rBCG) vaccine candidate induces improved protection against tuberculosis over parental BCG (pBCG) in preclinical studies and has successfully completed a phase 2a clinical trial. However, the mechanisms responsible for the superior vaccine efficacy of rBCG are still incompletely understood. Here, we investigated the underlying biological mechanisms elicited by the rBCG vaccine candidate relevant to its protective efficacy.

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