Stereoselectivity of an ω-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one
2009; Elsevier BV; Volume: 20; Issue: 5 Linguagem: Inglês
10.1016/j.tetasy.2009.03.012
ISSN1362-511X
AutoresKirsty Smithies, Mark E. B. Smith, Ursula Kaulmann, James L. Galman, John M. Ward, Helen C. Hailes,
Tópico(s)Microbial Natural Products and Biosynthesis
ResumoThe stereoselectivity of a recently isolated ω-transaminase from Chromobacterium violaceum in the amination of 1,3-dihydroxy-1-phenylpropan-2-one has been determined. The enzyme is not enantioselective towards a racemic mixture of 1,3-dihydroxy-1-phenylpropan-2-one but is highly stereoselective forming (2S)-2-amino-1-phenyl-1,3-propanediols in >99% ee.
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