p21WAF1/Cip1 is not involved in kainic acid-induced apoptosis in murine cerebellar granule cells
2004; Elsevier BV; Volume: 1030; Issue: 2 Linguagem: Inglês
10.1016/j.brainres.2004.09.052
ISSN1872-6240
AutoresEster Verdaguer, Elvira G. Jordà, Anna M. Canudas, Andrés Jiménez, Jaume Folch, Víctor Rimbau, Mercè Pallàs, Antoni Camins,
Tópico(s)DNA Repair Mechanisms
ResumoKainic acid (KA) treatment induced neuronal death and apoptosis in murine cerebellar granule cells (CGNs) cultures from both wild-type and knockout p21−/− mice. There was not statistically significant difference in the percentage of neuronal apoptosis among strains. KA-induced neurotoxicity was prevented in the presence of NBQX (20μM) and GYKI 52446 (20 μM), but not by z-VAD-fmk, suggesting that caspases are not involved in the apoptotic process. Data suggest that p21WAF/Cip was unable to modulate KA-induced apoptosis in murine CGNs.
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