Voltar
Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Synthesis, Characterization, and Cytotoxic Activity of Novel Platinum(II) Complexes Derived from N‐ Benzyl‐Ethylenediamine and Oxalate

2010; Wiley; Volume: 75; Issue: 4 Linguagem: Inglês

10.1111/j.1747-0285.2009.00941.x

ISSN

1747-0285

Autores

Heveline Silva, Vincent Barra, Fillipe V. Rocha, Mauro Vieira de Almeida, Eloi Teixeira César, Luciana M. Da Silva Siqueira, Míriam Teresa Paz Lopes, Ana Paula Soares Fontes,

Tópico(s)

Click Chemistry and Applications

Resumo

This work describes the synthesis and characterization of three novel complexes derived from N-benzyl-ethylenediamine and oxalate. Precursor compounds were synthesized by reacting N-benzyl-ethylenediamine with K(2)PtCl(4). Subsequent substitution of chlorides by oxalate led to the final products. Elemental analysis and the infrared, (1)H, (13)C, and (195)Pt NMR spectra of these complexes were provided. The cytotoxic activities were investigated against human non-small cell lung carcinoma (A(549)), mouse non-metastatic cell skin melanoma (B16-F1), mouse metastatic cell skin melanoma (B16-F10), human cell breast adenocarcinoma (MDA-MB-231) and normal cell lines such as baby hamster cell kidney (BHK-21), hamster cell ovary (CHO) and compared to cisplatin and carboplatin under the same experimental conditions. The presence of oxalate as a leaving group conferred an interesting cytotoxicity profile to the complexes in the tested cell lines.

Referência(s)