Portal de Periódicos da CAPES

Cyclic AMP-Induced Repair of Zebrafish Spinal Circuits

2004; American Association for the Advancement of Science; Volume: 305; Issue: 5681 Linguagem: Inglês

10.1126/science.1098439

1095-9203

Dimple H. Bhatt, Stefanie Otto, Brett Depoister, Joseph R. Fetcho,

Zebrafish Biomedical Research Applications

Neurons in the human central nervous system (CNS) are unable to regenerate, as a result of both an inhibitory environment and their inherent inability to regrow. In contrast, the CNS environment in fish is permissive for growth, yet some neurons still cannot regenerate. Fish thus offer an opportunity to study molecules that might surmount the intrinsic limitations they share with mammals, without the complication of an inhibitory environment. We show by in vivo imaging in zebrafish that post-injury application of cyclic adenosine monophosphate can transform severed CNS neurons into ones that regenerate and restore function, thus overcoming intrinsic limitations to regeneration in a vertebrate.