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Synthesis of 4‐oxo‐4 H ‐quino[2,3,4‐ i,j ][1,4]‐benoxazine‐5‐carboxylic acid derivatives

1987; Wiley; Volume: 24; Issue: 2 Linguagem: Inglês

10.1002/jhet.5570240228

1943-5193

Daniel T. W. Chu, Robert E. Maleczka,

Synthesis and Reactivity of Heterocycles

Abstract The synthesis and antibacterial activity of 1‐substituted amino‐2‐fluoro‐4‐oxo‐4H‐quino[2,3,4‐i,j][1,4]benox‐azine‐5‐carboxylic acid derivatives is described. Key steps in the synthesis include carbon homologation and two intramolecular nucleophilic displacement cyclization reactions to generate the 4‐oxo‐4H‐quino[2,3,4‐i,j]‐[1,4]benoxazine‐5‐carboxylic acid nucleus.