Reversal of respiratory responses to dopamine after dopamine antagonists
1982; Elsevier BV; Volume: 47; Issue: 2 Linguagem: Inglês
10.1016/0034-5687(82)90114-1
ISSN1872-7611
Autores Tópico(s)Sleep and Wakefulness Research
ResumoThe effects of dopamine (DA) antagonists upon resting ventilation and ventilatory reactions to DA, apomorphine, hyperoxia and hypoxia wre studied in pentobarbitone-anesthetized cats. Intravenous administration of spiroperidol, haloperidol, perphenazine and chlorpromazine increased resting ventilation, the intensity and duration of the effect being dependent on the dose of the blocker. The enhanced ventilation was associated to increased frequency of chemosensory discharges recorded from one carotid nerve, and it was absent after section of the four buffer nerves. The drugs also provoked a dose-dependent block of the transeint chemosensory inhibitions and ventilatory depressions induced by DA or apomorphine. In addition, spiroperidol andperphenazine reversed the inhibitory reactions to DA into excitatory ones, the ventilatory respnses being abolished by section of carotid and aortic nerves by a few breaths of 100% N2 persisted after applying DA blockers. Results indicate that DA antagonists enhance ventilation by increasing perpheral chemosensory drive and may invert DA-induced reflex withdrawal into transient excitation, without reversing the reflex ventilatory depression provoked by hyperoxia.
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