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DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters

2012; Oxford University Press; Volume: 41; Issue: D1 Linguagem: Inglês

10.1093/nar/gks1177

1362-4962

Natsuko Ichikawa, Machi Sasagawa, Mika Yamamoto, Hisayuki Komaki, Yumi Yoshida, Shuji Yamazaki, Nobuyuki Fujita,

Microbial Metabolic Engineering and Bioproduction

This article introduces DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated, http://www.bio.nite.go.jp/pks/), a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis. Bacterial secondary metabolites often show pharmacologically important activities and can serve as lead compounds and/or candidates for drug development. Biosynthesis of each secondary metabolite is catalyzed by a number of enzymes, usually encoded by a gene cluster. Although many scientific papers describe such gene clusters, the gene information is not always described in a comprehensive manner and the related information is rarely integrated. DoBISCUIT integrates the latest literature information and provides standardized gene/module/domain descriptions related to the gene clusters.