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Myositis-specific and myositis-associated autoantibody profiles and their clinical associations in a large series of patients with polymyositis and dermatomyositis

2013; Elsevier BV; Volume: 68; Issue: 7 Linguagem: Inglês

10.6061/clinics/2013(07)04

1980-5322

Marcela Gran Pina Cruellas, Vilma dos Santos Trindade Viana, Maurício Levy‐Neto, Fernando Henrique Carlos de Souza, Samuel Katsuyuki Shinjo,

Skin Diseases and Diabetes

OBJECTIVE:To analyze the prevalence of myositis-specific and myositis-associated autoantibodies and their clinical correlations in a large series of patients with dermatomyositis/polymyositis.METHOD: This cross-sectional study enrolled 127 dermatomyositis cases and 95 polymyositis cases.The diseaserelated autoantibody profiles were determined using a commercially available blood testing kit.RESULTS: The prevalence of myositis-specific autoantibodies in all 222 patients was 34.4%, whereas myositisassociated autoantibodies were found in 41.4% of the patients.The most frequently found autoantibody was anti-Ro-52 (36.9%), followed by anti-Jo-1 (18.9%), anti-Mi-2 (8.1%), anti-Ku (4.1%), anti-SRP (3.2%), anti-PL-7 (3.2%), anti-PL-12 (2.7%), anti-PM/Scl75 (2.7%), and anti-PM/Scl100 (2.7%).The distributions of these autoantibodies were comparable between polymyositis and dermatomyositis, except for a higher prevalence of anti-Jo-1 in polymyositis.Anti-Mi-2 was more prevalent in dermatomyositis.Notably, in the multivariate analysis, anti-Mi-2 and anti-Ro-52 were associated with photosensitivity and pulmonary disorders, respectively, in dermatomyositis.Anti-Jo-1 was significantly correlated with pulmonary disorders in polymyositis.Moreover, anti-Ro-52 was associated with anti-Jo-1 in both diseases.No significant correlation was observed between the remaining autoantibodies and the clinical and/or laboratory findings.CONCLUSIONS: Our data are consistent with those from other published studies involving other populations, although certain findings warrant consideration.Anti-Ro-52 and anti-Jo-1 were strongly associated with one another.Anti-Ro-52 was correlated with pulmonary disorders in dermatomyositis, whereas anti-Jo-1 was correlated with pulmonary alterations in polymyositis.